TIMP3 and diabetes mellitus: TIMP‐3 facilitates in bone formation,13 bone fracture healing, and overexpressed TIMP‐3 could contribute to recovery from diabetes.14 Moreover, TIMP‐3 might be the target of miR‐222.15, 16 Therefore, we assume that miR‐222 negatively affects bone fracture healing by mediating TIMP‐3 in diabetes, and we used femoral fracture rat model injected with STZ to induce diabetes, then treated with miR‐222 mimic or inhibitor to support our hypothesis.