Oshima et al reported that TNIP1 requires ubiquitin binding to restrict cell apoptosis.33 In addition, TNF has been implicated in cellular communication, cell differentiation and cell death, and is associated with diverse diseases, including cancers.34 Under normal physiological conditions, TNF signalling can elicit pro‐apoptotic or anti‐apoptotic pathways. This evidence concerns the gene TNF and cancer.