Ubiquitin binding and the NEMO (UBAN) domain of mutant TNIP1 fail to interact with linear deubiquitin chains, leading to liberation of the NF‐κB signalling pathway.44 The UBAN domain is reported to interact with both linear and Lys 63‐linked chains under various cellular contexts, but with a preference for linear deubiquitin chains.45, 46, 47, 48, 49 In our work, however, TNF‐α–induced NF‐κB activation benefited from high levels of TNIP1, and down‐regulation of TNIP1 reduced P65 activation in glioma cells. This evidence concerns the gene IKBKG and central nervous system cancer.