TNIP1 and TNFα‐induced NF‐κB activity play key roles in immune diseases and inflammatory responses.23 Genetic polymorphisms of TNIP1 are also reportedly correlated with elevated risk of gastric carcinoma or glioma prognosis 24, 25; however, the detailed roles of TNIP1 in glioma still remain to be elucidated. This evidence concerns the gene TNIP1 and central nervous system cancer.