TNF and anemia (phenotype): TNIP1, also known as ABIN1, is widely expressed in human tissues.11 TNIP1−/− mice display normal Mendelian ratios before embryonic day 18.5 but die during late embryogenesis (2.4% born versus 25% expected) from foetal liver apoptosis, anaemia and hypoplasia.12 Furthermore, embryonic fibroblasts from TNIP‐1−/− mice are hypersensitive to tumour necrosis factor (TNF)‐induced programmed cell death, with lethality reduced by crossing with mice without TNF receptor type I.12 Therefore, TNIP1 is essential for TNF‐induced programmed cell death in normal tissue.