TNF and central nervous system cancer: For example, NF‐κB signalling is responsible for sustaining the anti‐apoptotic properties of Bcl2 and Bcl‐XL, the classical apoptosis carried out by caspase 9 and caspase 3.35, 36, 37, 38 In our observations, TNF‐α treatment immediately activated P65 (a subunit of NF‐κB) in normal glioma cells, which was remarkably attenuated in the TNIP1‐interfered glioma cells.