Receiver operator characteristic curve analysis revealed that serum levels of SPON2 differentiated patients with GC from healthy individuals (AUC = 0.892; 95% CI, 0.829‐0.954; P < .001; cut‐off value for diagnosis of GC, 10.52; diagnostic sensitivity below the cut‐off, 77.1%; and specificity, 84%; Figure 2E). The gene discussed is SPON2; the disease is gastric cancer.