SPON2 and gastric cancer: IHC analysis demonstrated that high expression of SPON2 was significantly associated with T‐ and N‐staging, OS and DFS, which is consistent with the findings of Jin et al.32 Moreover, SPON2 expression was significantly increased in GC tissues from patients with metastasis and relapse 3 years after surgery, suggesting that SPON2 overexpression is associated with relapse and metastasis.