SPON2 and hepatocellular carcinoma: This is the reason why SPON2 has increased transcription levels in some types of HCC tissues.33 The non‐coding RNAs that are abnormally expressed can also first increase the expression level of its target gene SOX13, and then activating the promoter region of SPON2 by SOX13 to increase the expression level of SPON2 in glioma tissues.34 There may be similar thyroid hormone and non‐coding RNA expression abnormalities in GC tissues, which requires further study in the future.