GLP1R and steatosis: In addition, it has been shown in animal models that endogenous GLP-1 or GLP-1RAs exert pleiotropic actions in organs such as the liver and heart, and in animal studies it has been found that GLP-1 receptor (GLP-1R) agonism can decrease hepatic [5–7] and myocardial [8] steatosis, independent of weight loss.