Tumors also secrete other factors well known to mobilize EPCs to the tumor bed and promote neovascularization, including chemokines C–C motif ligand (CCL)2 and CCL5, the hypoxia responsive chemokine CXCL12 (also known as SDF-1) [55] and adiponectin [55–57]. This evidence concerns the gene CCL2 and neoplasm.