The domain of p62 that engages Tax by direct interaction (amino acids 170 to 221) encompasses the MIR (for Multiple Protein Interaction Region) through which several proteins are known to bind p62, including the LIM domain protein Ajuba50, p38 MAPK51, a familial amyotrophic lateral sclerosis (ALS) mutant of superoxide dismutase (SOD1)52 and the autophagy adapter ALFY53. Here, SOD1 is linked to amyotrophic lateral sclerosis.