Although alterations in TRPV2 expression in cancer cells or the involvement of TRPV2 in cancer functions have been reported in several types of carcinomas including esophageal squamous cell carcinoma (ESCC)18, the oncological and physiological roles of TRPV2 in ESCC have remained unclear. Here, TRPV2 is linked to esophageal squamous cell carcinoma.