TRPV2 and neoplasm: Liberati et al. interpreted this discrepancy as TRPV2 playing a major role in initial events that parallel the transformation of a single normal stem/progenitor cell into a tumor cell, while the expression of TRPV2 was modulated during carcinogenesis that followed long-term and continuous exposure to different carcinogenetic agents, resulting in tumor growth, progression, and the selection of more aggressive tumor clones16.