As high levels of lncNB1, RPL35, E2F1, and DEPDC1B expression in tumor tissues correlate with poor prognosis in neuroblastoma patients, our findings identify lncNB1, RPL35, and DEPDC1B as important co-factors for N-Myc-driven oncogenesis and provide therapeutic targets for neuroblastoma. Here, E2F1 is linked to neuroblastoma.