Furthermore, NICI expression is regulated by the von Hippel–Lindau (VHL) tumor suppressor and is highly expressed in clear cell renal cell carcinoma (ccRCC), where SLC2A3 expression is associated with patient prognosis, implying an important role for the HIF/NICI/SLC2A3 axis in this malignancy. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.