TLR2 signaling is closely related to autophagy induction and flux (72) and plays important roles in innate immune responses to several bacterial infections, including Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Mycobacterium tuberculosis infections (73, 74), and in the regulation of inflammation (75). Here, TLR2 is linked to bacterial infectious disease.