Autophagy is involved in limiting the type I IFN response by (i) clearing the RIG-I pathway proteins in autophagy-deficient Ras-driven cancer cells (70), (ii) degrading NF-κB signaling components (71) and IRF3 by TRIM21-mediated selective degradation, and (iii) interfering with RLR-IPS1 interaction-driven downstream signaling. The gene discussed is IRF3; the disease is cancer.