In human, UNC80 and NALCN mutations are the causes of complex syndromic diseases (Köroğlu et al. 2013; Al-Sayed et al. 2013; Perez et al. 2016; Stray-Pedersen et al. 2016; Fukai et al. 2016; Bramswig et al. 2018) that are collectively called NALCN channelopathies (Bramswig et al. 2018). This evidence concerns the gene UNC80 and channelopathy.