The impact of chronic TCR-A2 (self)-interactions on tumor-redirected A2pos CD8 T cells upon TCR transduction of increased affinities led to the co-expression of multiple inhibitory receptors such as PD-1, TIM-3, TIGIT and 2B4, that preceded T cell hyporesponsiveness (Fig. 3). The gene discussed is CD8A; the disease is neoplasm.