Despite the fact that the N-terminal pro B-type natriuretic peptide (NT-proBNP) is considered as the Gold Standard biomarker in heart failure MR-proANP emerges as a valuable biomarker for the prediction of death and heart failure related events in patients with hypertrophic cardiomyopathy and has shown similar diagnostic performance when compared with NT-proBNP [29–31]. This evidence concerns the gene NPPA and heart failure.