We identified 9 RTKs that were significantly phosphorylated in the primary ccRCC samples and 6 of which, Insulin R, HGFR, PDGFRβ, M-CSFR, VEGFR1, and VEGFR2, were specific to the ccRCCs samples comparing to their adjacent normal tissues. Here, PDGFRB is linked to nonpapillary renal cell carcinoma.