MKI67 and breast cancer: Table 1 and Fig. 1 present the prognostic effect of the expression of SPAG5. In addition, we compared and correlated SPAG5 with other markers of progression, such as p53, AURKA, MKI67 and BIRC5, to assess independent value, and results showed that similar to AURKA, MKI67, BUB1, TOP2A which had statistically significant results for RFS, SPAG5 was associated with breast cancer progression.