SPAG5 and breast cancer: However, in patients who received chemotherapy, no significant difference existed between low and high SPAG5 transcript expressions in RFS (HR = 1.1, 95% CI 0.74–1.63, p = 0.64) and OS (HR = 1.54, 95% CI 0.74–3.2, p = 0.25) of breast cancer patients.