FZD6 and cancer: Some of the transcription factors that were specifically expressed in OS-DW cells were ATF6, CDX2, FOSL1, PRDX3, FZD6, MYNN, TRAF1 which are known to regulate pathways implicated in cancers like, Wnt/Hedgehog/Notch signaling, MAPK signaling, Apoptosis and mTOR signaling (Fig. 1b).