This included genes like, PIK3R2, PIK3CA, BIRC2 and ZBTB14 with implications in cancer [34–38] that were over-expressed with FC above ≥10 in OS-DW in comparison to OS-R; while, expression of WNT5A, PIK3CB, ACVR1, MAPK13 and GBX2 were significantly reduced [39–47] (Fig. 1c). Here, ACVR1 is linked to cancer.