For example, using the same CIMP-3 marker panel with the same CIMP-high criterion, Ogino and colleagues found that CRABP1, IGF2, and NEUROG1 demonstrated very good sensitivity (≥95%), whereas CACNA1G, MLH1, RUNX3, and SOCS1 showed superior specificity (≥90%) in 920 American CRC cases [32]. This evidence concerns the gene MLH1 and colorectal carcinoma.