RBPJ and graft versus host disease: While one model used conditional loss of RBP-Jκ in Tregs to suggest that Notch signalling in Tregs is the essential driver of GVHD protection [64], side-by-side conditional deletion of Notch signalling in Tregs alongside Tconvs revealed that Notch inhibition in Tconvs remained essential for conferring protection from GVHD [65].