In particular, it has been reported that DGKα is over expressed in hepatocellular carcinoma15, and melanoma cells11 while other reports suggested that the growth of colon and breast cancer cell lines was significantly inhibited by DGKα-siRNA16 and DGKα/atypical PKC/β1 integrin signalling pathway was crucial for matrix invasion of breast carcinoma cells.17 This evidence concerns the gene DGKA and melanoma.