It is important to notice that HLA-E is upregulated in melanoma [81], colorectal cancer [82,83,84,85], non-small cell lung carcinoma [86], serous ovarian carcinoma [87], and gynecological cancers [88], suggesting that HLA-E plays an important role in the progression of these malignancies, probably, by inhibiting NKG2A+ killer lymphocytes. Here, HLA-E is linked to colorectal cancer.