Recent studies have shown that ZIKV can interfere with interferon-induced responses: ZIKV infection inhibits STAT1 and STAT2 phosphorylation [16], and especially ZIKV NS5 protein inhibits STAT1 phosphorylation [15] and induces the proteasomal degradation of STAT2 [15,17,18,19]. Here, STAT2 is linked to Zika virus infectious disease.