Renal anomalies are found in around 40% of the ALGS patients with mutations in JAG1. The ALGS associated renal anomalies include multicystic dysplastic kidneys, renal tubular acidosis, vesicoureteral reflux, obstruction, chronic renal failure, end-stage renal disease, acute kidney injury, renal lipidosis, renal artery stenosis, focal segmental glomerulosclerosis, duplex collecting system, and other renal diseases in a minor proportion [91,94]. The gene discussed is JAG1; the disease is kidney disorder.