TP53 and neoplasm: The results showed that TP53WT CRCs were significantly enriched in 61 KEGG pathways (p < 0.05) (Supplemental Table S1), including pathways that were involved in immune signaling: T-cell-receptor-signaling-pathway, B-cell-receptor-signaling-pathway, intestinal-immune-network-for-IGA-production, and tumor proliferation, apoptosis and migration related signaling pathways, such as JAK-STAT-signaling-pathway, apoptosis, MAPK-signaling-pathway, and P53-signaling-pathway (Figure 1b,c).