A study demonstrated that grape exosome-like nanoparticles (GELNs) could penetrate the intestinal mucus barrier and were taken up by mouse intestinal stem cells, causing a significant induction of Lgr5 intestinal stem cells through the Wnt/β-catenin pathway and protecting the mice from dextran sulphate sodium (DSS)-induced colitis [12]. The gene discussed is LGR5; the disease is colitis.