DOT1L and cancer: A recent genome-wide CRISPR–Cas9 loss-of-function genetic screen to identify genes essential for proliferation and survival of cancer cells (indicated as “Achille” genes) [28] showed that DOT1L, whose expression correlates with a worse clinical behavior in OC patients (Supplementary Figure S6A) is required for optimal survival in about 60% of all investigated OC cells (Supplementary Figure S6B).