ANGPTL4 and obesity due to melanocortin 4 receptor deficiency: In these mice, the protection against obesity and hepatic steatosis may be possibly explained by higher circulating levels of Angiopoietin-like 4 (ANGPTL4), a serum hormone that impaired fat storage in adipocytes, muscles and heart and by the ability of microbiota to cleave and ferments complex dietary plant polysaccharides [39].