Specifically, VSL#3 reversed IR, prevented development of histologic features of mesenteric adipose tissue inflammation, NASH and reduced the extent of aortic plaques, through the modulation of Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ), FXR and vitamin D receptor [122]. Here, NR1H4 is linked to metabolic dysfunction-associated steatohepatitis.