PCa resistance to a therapy is associated with the abnormally increased expression of Bcl-2, and androgens receptor (AR), epidermal growth factor receptor (EGF), HER2 (human epidermal growth factor receptor 2), cyclic D1, and cyclone-oxygenize (COX-2), and all of them are connected to the activation of the transcription factor NF-kB. The gene discussed is BCL2; the disease is posterior cortical atrophy.