CD4 and glioblastoma: The native form of Goodpasture antigen does not bind to B cell receptors, but CD4+ helper T cells recognize Goodpasture antigen in the linear peptide form bound to human leucocyte antigen (HLA) class II molecule on surface antigen-presenting cells.[4,5] Anti-GBM disease is therefore considered a type of T cell disorder disease in the certain HLA such as HLA-DR15 with DNA type HLA-DRB1∗1501.[4–6]