ACE and hypertensive disorder: Differential diagnosis of secondary arterial hypertension is essential in children due to the fact that it might be the result of other causes, including different life-threatening intoxications.[25] Angiotensin-converting enzyme inhibitors represent the first-line therapy for this type of hypertension despite the scarcity of available studies, along with calcium-channel blockers, diuretics, and beta-blockers.[26] In case of these patients, the risk of urinary tract infections is high, which require adequate monitoring and early antibiotic treatment to prevent further renal injuries.