CD2 and lymphoma: Nasal type ENKTCL seems to be caused by EBV, and EBER in situ hybridization is the most reliable way to demonstrate the presence of EBV, which can be achieved from paraffin-embedded tissues.[3] Meanwhile, this type of lymphoma arises as a consequence of malignant transformation of NK-cells (NKCs) which express markers CD56+, TIA-1, and lack T-cell receptor (TCR) gene rearrangements, the tumor cells typically have the immunophenotype of CD56+, CD2+, and cytoplasmic CD3+.[4–6] Since CD56 is recognised as a NKC antigen, the tumor is termed NK T-cell lymphoma.