Interestingly, at 20 weeks after TAA administration, H&E (hematoxylin and eosin) staining revealed that the loss of FoxA2 resulted in early and profound dysplastic changes in the biliary epithelium, which subsequently progressed to biliary cytokeratin (CK19)-expressing invasive ICC. This evidence concerns the gene FOXA2 and intrahepatic cholangiocarcinoma.