LOX and diabetes mellitus: Taken together, our findings that dopamine inhibits strong GIP‐stimulated LOX production in osteoblasts, combined with significantly elevated serum levels of dopamine observed in the diabetic mice, and partial restoration of LOX levels and near full recovery of trabecular bone structure by amisulpride, point to the conclusion that elevated gut‐derived dopamine in diabetes is a major mechanism of diabetic bone disease.