LOX and diabetes mellitus: Interestingly, an early study in copper‐deficient birds that exhibited osteolathyrism and low LOX activity, when supplemented with increasing levels of copper, indicated that bone LOX activity that is as low as 20% of normal control levels was sufficient to restore collagen crosslinking and bone strength.47 Here we have shown that LOX mRNA levels are reduced to nearly undetectable levels in bone and osteoblasts by diabetes, and that in vivo amisulpride supplementation to diabetic mice increases LOX levels by threefold.