Studies of bone abnormalities in type I diabetes may have a degree of relevance to type II diabetes mellitus because both result in hyperglycemia and increased rates of hip and foot fractures that appear to be independent of BMD changes.6 In the type I mouse model, we show that diabetic bone has impaired collagen structure, severe trabecular defects, and decreased LOX RNA levels that appear to mediate diabetes’ effects on bone health. This evidence concerns the gene LOX and type 2 diabetes mellitus.