This result may be related to two conditions: (1) migration of cells to the organs affected by LPF, such as the liver (leukocyte infiltration in the portal system and sinusoids) and the lung (interstitial pneumonitis), and (2) lower generation of leukocytes in the bone marrow due to the increased concentration of IFN-γ and TNF-α in the serum of A/J C5−/− mice. The gene discussed is TNF; the disease is Interstitial pneumonitis.