An experimental model of anemia also demonstrated the suppressive role of these cytokines on hematopoietic progenitors [52, 53] supporting the hypothesis of a relationship between the decrease in the number of leukocytes on the third day with the increase of IFN-γ and TNF-α in the serum of both A/J C5+/+ and A/J C5−/− mice. Here, IFNG is linked to anemia (phenotype).