The results of the present study showed that the two growth factors namely Granulocyte-Colony Stimulating Factor (G-CSF, Lenograstim) and the recombinant human Granulocyte-Macrophage Colony Stimulating Factor (rHu GM-CSF, Molgramostim, Mielogen), exhibited favourable influence on experimental chemical colitis in rats. The gene discussed is CSF2; the disease is colitis.