The results of our study conducted to determine the relationship between DM and oral oncogenesis led us to think that early-onset degeneration occurring due to the absence of dysplasia, capillary proliferation, and MNL infiltration as well as not changing bcl2, p53, and Ki67 expressions might be related to p16 and its accelerating effect of aging (shortening of filiform papillae length and width and reduction in epithelial thickness). Here, BCL2 is linked to diabetes mellitus.