EGFR and central nervous system cancer: To improve the gliomas targeting effect after the carrier crossing BBB, another peptide targeting epidermal growth factor receptor (EGFR) was screened through a “one-bead one-compound” (OBOC) combinatory library and conjugated on the dendrimer simultaneously as increased gene amplification and protein overexpression of EGFR has been found in almost 50% of glioma patients 3.