According to the KEGG analysis, 15 pathways were significantly altered in hub modules including glutathione metabolism, wnt signaling pathway, central carbon metabolism in cancer, mTOR signal, pancreas secretion, protein digestion or absorption, axon guidance, retinol metabolism, insulin secretion, salivary secretion, and fat digestion and absorption (Fig. 4; Table 2). The gene discussed is MTOR; the disease is cancer.