Of the 358 genes, a total of 15 genes (SOX2, KIT, PRSS56, WNT9A, SLC4A4, PRRG4, PANX2, PIR, RASSF8, MFSD4A, INS, RNF39, IL1R2, CST1, and PPP3CA) demonstrated significant association with the prognosis of CCA (Table 3). The gene discussed is IL1R2; the disease is cholangiocarcinoma.