In conclusion, this study has provided support for the extreme male brain hypothesis of autism, in showing that females with the GG genotype for the SNP rs3802890, in the autophagy-activating gene AMBRA1, exhibit male-like, or male-exceeding, scores on AQ-Imagination, the most male-biased of subscales on the Autism Quotient test. The gene discussed is AMBRA1; the disease is autism.