This model reproduces many key features of clinical asthma such as elevated levels of allergen‐specific IgE, airway inflammation, goblet cell hyperplasia, epithelial hypertrophy, and airways hyperresponse47 and represents the most used preclinical model that resulted very useful to elucidate different aspects of the pathology of the disease and to search for new therapeutic treatments. The gene discussed is IGHE; the disease is asthma.