Dectin-3 can also recognize TDM and induce Mincle expression upon Mycobacterium infection via CARD9–Bcl-10–MALT1-dependent NF-κB activation and the increased Mincle expression can enhance the ability of host innate immune system to sense Mycobacterium infection [64]. The gene discussed is CLEC4E; the disease is Mycobacterium infection.