Additionally, paraplastic hepatocytes are one of the main causes of liver fibrosis, and RT-PCR and Western blotting analyses showed that cyclin D1 expression levels were apparently lower in the KLF4-overexpressing mice than in those treated with the null plasmid prior to CCl4 administration (Figures 2(f) and 2(g)). Here, KLF4 is linked to Hepatic fibrosis.