In LPS-induced RAW 264.7 cells, we showed that AL-1 significantly reduced the generation of ROS and NO, decreased the expression of inflammatory cytokines, and repressed nuclear translocation of NF-κB. Our results demonstrated that AL-1 inhibited the expression of p-IκBα, p-p65, and p-MAPKs in mice and in macrophage cells, suggesting that AL-1 prevented DSS-induced ulcerative colitis in mice and LPS-induced inflammation in macrophage cells possibly via downregulation of the NF-κB and MAPK signaling pathways (Figure 9). Here, NFKBIA is linked to ulcerative colitis.