NFE2L2 and viral infectious disease: The treatment of MG132 (1 μM) partially restored the Nrf2 depletion induced by the virus infection, and its protein level was increased to ~3.5-fold relative to the mock-treated infected control (Figures 3(a) and 3(b)), indicating that the ubiquitin proteasome pathway was potentially involved in the Nrf2 depletion in virus-infected cells.