However, NRF1 and NRF2 mRNA correlated with melanoma patients' gender (higher mRNA levels in males, p = 0.037 and p = 0.017, n = 20 and n = 19, respectively), and NRF1 mRNA also correlated positively with the presence of ulceration (p = 0.016, n = 18). The gene discussed is NRF1; the disease is melanoma.