SERPINE1 and Cowden syndrome 1: With respect to the analysis of genotype and allele frequencies of the 4G/5G PAI-1 polymorphisms, a significant difference for the 5G allele frequency (33% versus 30.5% in MS and CS, respectively, p = 0.04) and 5G/5G genotype frequency (11.5% vs. 5.5% in MS and CS, respectively, p = 0.02) was observed.