NY-SEO-1, EGFR, PLAP, and EpCam were high in exosomes isolated from the plasma of lung cancer patients [111], and Vykoukal et al also revealed that SGRN, TPM3, THBS1, and HUWE1 levels in plasma-derived exosomes in lung cancer patients is higher than control group [112]. This evidence concerns the gene HUWE1 and lung carcinoma.