RTL1 protein was also detected in the regenerating myofibers of mdx muscle, as were transcripts in muscle biopsies from patients diagnosed with Emery-Dreifuss Muscular Dystrophy (AD-EDMD) caused by LMNA mutations, indicating that RTL1 expression may be a general requirement of muscle regeneration. The gene discussed is RTL1; the disease is Emery-Dreifuss muscular dystrophy.