The present study aimed to evaluate the associations between blood pressure and selected gene polymorphisms with GWAS-recognized effects on blood pressure control (rs3184504 of the SH2B3 gene, rs1327235 of the JAG1 gene, rs13139571 of the GUCY1A3-1B3 gene, and rs1173771 of the NPR3c5orf23 gene) in individuals referred to a sleep laboratory for OSA evaluation. The gene discussed is SH2B3; the disease is obstructive sleep apnea syndrome.