HTT and Huntington disease: Although there is no correlation between the number of AR inclusion bodies and neurodegeneration in a Drosophila model of SBMA [153]—in agreement with the finding that fully formed inclusion bodies of polyQ-expanded huntingtin are associated with a reduced risk of death in a cell model of HD [154]—it is clear that AR aggregation disrupts normal cellular function at least partially via the sequestration of other proteins.