CD8A and renal cell carcinoma: Transduced CD8+ T-cells with or without native TRAC disruption expressing HD_A-15 or HD_C-17 TCRs were re-tested for recognition of 5T4+/HLA-A2+ RCC (A498, BB65, DOBSKI) versus control targets demonstrating preserved lytic potency for the 5T4+/HLA-A2+ RCC lines and absent recognition of the control targets, including the HLA-mismatched SST548 RCC or 5T4-negative targets BB65-LCL and HLA-A2+/5T4− fibroblast lines (Fig. 4c and Supplementary Fig. 5).